Custom antibody engineering and development services using advanced molecular biology and protein engineering techniques for specific applications.
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Computational and library-based approaches to increase binding affinity by 10-100 fold.
Precision CDR-grafting and framework optimization to minimize immunogenicity in therapeutic candidates.
Expert engineering of novel formats (e.g., DVD-Ig, scFv-Fc) for dual-targeting applications.
Custom antibody engineering allows precise modification of antibody structure to improve therapeutic properties. NTSR provides a comprehensive suite of services, from humanization and affinity maturation to the design of novel bispecific formats, backed by structural biology and computational modeling.
| Parameter | ScFv / VHH | Full IgG | Bispecifics |
|---|---|---|---|
| Format type | Single chain / Nanobody | Standard / Humanized | Dual antigen targeting |
| Binding affinity (KD) | pM to nM range | High pM range | Customizable |
| Cloning strategy | Library display | Phage / Mammalian | Complex assembly |
| Purification mode | His-Tag / SEC | Protein A/G | Multi-step SEC |
Share your target and desired antibody format and we’ll propose an engineering workflow.
Start an Antibody Engineering request