NTSR
Custom antibody engineering and development services using advanced molecular biology and protein engineering techniques for specific applications.
Custom antibody engineering allows for the precise modification of antibody structure to improve therapeutic properties. NTSR provides a comprehensive suite of engineering services, from humanization and affinity maturation to the design of novel bispecific formats. Our expertise in structural biology and computational modeling ensures that every modification maintains structural integrity while maximizing target specificity and binding strength.
Computational and library-based approaches to increase binding affinity by 10-100 fold.
Precision CDR-grafting and framework optimization to minimize immunogenicity in therapeutic candidates.
Expert engineering of novel formats (e.g., DVD-Ig, scFv-Fc) for dual-targeting applications.
| Parameter | ScFv / VHH | Full IgG | Bispecifics |
|---|---|---|---|
| Format Type | Single Chain / Nanobody | Standard / Humanized | Dual Antigen Targeting |
| Binding Affinity (KD) | pM to nM Range | High pM Range | Customizable |
| Cloning Strategy | Library Display | Phage / Mammalian | Complex Assembly |
| Purification Mode | His-Tag / SEC | Protein A/G | Multi-step SEC |